Sep 11, 2014 lsd, ecstasy mdma and other psychedelics are powerful, mindaltering drugs that, as described by former washington post magazine editor tom shroder, intrinsically challenge the rationalist. He is credited with introducing mdma ecstasy, mandy or molly to. The only difference is that it doesnt inhibit the reuptake of seritonin as much as dopamine, whereas mdma equally affects the seritonin and dopamine. More recently, a baggy of molly short for molecular mdma that you dip into over the party, has replaced the pill as the defacto vehicle for consumption. Saying you plan on synthesizing mdma and doing it are two different things.
Shulgin had only introduced the drug to west coast. Technological advances in refining, synthesizing, and manufacturing psychoactive drugs have increased their potency and abuse liability. Mdma or 3,4methylenedioxymethamphetamne is an indirect. He began synthesizing compounds from a rye fungus called ergot and eventually created lsd. What follows is, of course, a work of pure fiction. In the book strike tells the reader, step by step, how to prefrom the manufactor of mda, mdma, mdea, and whatever.
This book is only to be used for informational purposes, and all the info herein is gathered on the internet. If the file has been modified from its original state, some details may not fully reflect the modified file. The expertise needed in mdma production varies according to the route of synthesis. Timewise, this solid, balanced, multifaceted and comprehensive, ecstasy introduces most of the relevant perspectives for evaluating the promises and dangers of mdma. Mdma was first synthesized by germanys merck at the start of the 20th century, but it would be decades before a human tried a dose. In 1976, dow pharmaceuticals chemist alexander shulgin discovered mdmas effects after synthesizing a batch and testing 120 milligrams on himself. Mdma interferes with the metabolism of other drugs, including some of the adulterants in mdma tablets. Alexander theodore shulgin june 17, 1925 june 2, 2014 was an american medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. A complete mdma synthesis for the first time chemist 3. The history of psychedelics and psychotherapy timeline. Lsd, ecstasy mdma and other psychedelics are powerful, mindaltering drugs that, as described by former washington post magazine editor tom shroder, intrinsically challenge the rationalist. Mdma september 20 page 1 mdma ecstasy or molly mdma 3,4methylenedioxymethamphetamine, popularly known as ecstasy or, more recently, as molly, is a synthetic, psychoactive drug that has similarities to both the stimulant amphetamine and the hallucinogen mescaline. Bright stars mdma synthesis for the first time chemist. Stir so that the whole thing is mixed up real well now drip in muriatic acid slowly.
A comprehensive guide to synthesis update hello again from your neighborhood drug author, for those unaware, i am currently writing a textbook on the synthesisextraction of many drugs and their precursors, the laws regarding the same drugs and precursors. Pharmacokinectic studies have shown that mdma is rapidly absorbed into the human blood stream, but once in the body the metabolites of mdma inhibit mdma metabolism. Since safrole and isosafrole, mdp2ppmk, and sassafrass oil are listed precursors in the us theyre very hard to find. The classic ketone approach certainly not the only possibility, but the best documented one has a lot of variations, but the basic scheme is the oxidation of the plant oil safrole 1allyl3,4methylenedioxybenzene into a ketone 3,4methylenedioxyphenyl2propanone, which is then condensed with methylamine and reduced to the final. As a result, subsequent doses of the drug produce unexpectedly high blood. The mdma ecstasy synthesis published in pihkal remains one of the most common clandestine methods of its manufacture to this. The synthesis of mdp2p from isosafrole will require the use of a vacuum pump to evaporate the solvent from the final product in vacuo.
Test with ph paper every 5 drops or so keep adding the muriatic acid until the ph of the solution is 56 or just. Confessions of a middleaged ecstasy eater books the. Synthesis of 4allylcatechol 3,4dihydroxyallylbenzene synthesis of 4allylcatechol mechanism of claisen rearrangement in catechols synthesis of safrole from catechol. A complete mdma synthesis for the first time chemist hip. A complete mdma synthesis for the first time chemist hip forums. The synthesis and characterisation of mdma derived from a. Drug researchers find mdmas serotonindepleting effects. The most popular way to convert safrole into mdma is by synthesizing the 3,4methylenedioxyphenyl2propanone mdp2p intermediate via the wacker process or by isomerizing safrole into isosafrole by a strong base. To a cooled mixture of 34 g 30% h2o2 and 150 g formic acid, add dropwise a solution of 32. In 1985, the dea declared an emergency ban on mdma, placing it on the list of schedule i drugs, defined as substances with no currently accepted medical use and a high potential for abuse. This led to mdma being scheduled internationally, and of course, the market moving to synthesize waves of novel psychoactive substances and iterations on the illegal substance. Angie becomes one of the west coasts largest distributors of x, cutting deals on campus and in posh nightclubs.
Mdma is manufactured by safrole, a liquid extract from sassafras trees. Anything below that is typically considered a subperceptual microdose. How did alexander shulgin become known as the godfather of. In 1959, an investigation into mdmas potential use as a stimulant was again undertaken, but the details have been lost. Read an organic lab techniques book on the subject its amazing what you can learn and how much you can retain when youre sufficiently motivated. In short the mdma oil can be an oil or an salt, the salt is water. Success that is to say, a nice little load of gleaming mdma crystals slowly drying on filter paper in your lab without attracting the attention of law enforcement requires a lot of caution andor a lot of luck.
Attempting to make mdma is extremely dangerous and can cause you permanent injury or kill you. Test with ph paper every 5 drops or so keep adding the muriatic acid until the ph of the solution is 56 or just barely acidic. The synthesis of mdp2p from isosafrole and the aluminum amalgam synthesis are probably the most useful. This genius chemist spent 50 years creating psychedelic drugs.
This file contains additional information, probably added from the digital camera or scanner used to create or digitize it. Also, you will never find or synth 100% pure molly, if anyone says that have 100% pure mdma they are lieing. The selfpublished book was half autobiography of shulgin and his wife ann, half account of his decades of research into psychedelic compounds, replete with instructions on the synthesis and dosage of hundreds of psychedelics, as well as vivid trip reports by shulgin and the small group of friends on whom hed test his latest creations. And thats without even getting into the dangers of exposure from selling drugs, should a profit be your motivation. Timewise, this solid, balanced, multifaceted and comprehensive, ecstasy introduces most of the relevant perspectives. Studies dont actually represent typical mdma users. She begins synthesizing mdma and becomes one of the largest distributors of ecstasy during the mid1980s. An asian american girl from the wrong side of the tracks is accepted into a prestigious university, only to succumb to her personal demons. This synth is slightly outdated and youre not going to help your friend unless you have some post secondary organic chemistry and lab experience under your belt, reading a textbook will not prepare you for exothermic reactions or setting up a vacuum distill. Synthesizing into the book is a reading comprehension resource for elementary students and teachers. Non of the herein shown pictures is taken by the producer of this book and thus the producer can not be held responsible for this syntheses seen on the pictures.
Mdma has properties that may make it attractive for psychotherapy, although many of its effects are potentially problematic. Contrary to expectation, mdma was discovered much earlier. Its exactly the same effects as mdma, but its methylenedioxymethcathinone instead of methylenedioxymethamphetamine. It was the twentyfifth substance in a series of lysergic acid derivatives, and hence, its official name was lysergic acid diethylamide abbreviated lsd25. Early studies from the 1980s noted that mdma was an entactogen, engendering feelings of love and warmth. Mdma was developed by a german pharmaceutical company in 1912. The reason why i post it is that this has to be one of the easier mdma synthesis that i have seen, it requires readily available chemicals such as h2o2, formic. For example, just put water into the system and go through the motions the first time. Mdma 3,4methylenedioxynmethylamphetamine is a synthetic amphetamine derivative that has both stimulant and hallucinogenic properties.
This formula is exemplified for mda 3,4methylenedioxy phenylisopropylamine. The real godfather of the drug, though, is a man named alexander sasha shulgin, a quirky psychopharmacologist from harvard who began synthesizing and selftesting mdma in the backyard of his. The sudden jolt from hardship to privileged campus life proves to be a challenge. This book is only to be used for informational purposes, and all the info herein is. When taken by mouth, effects begin in 30 to 45 minutes and last 3 to 6 hours. Dec 09, 2016 the selfpublished book was half autobiography of shulgin and his wife ann, half account of his decades of research into psychedelic compounds, replete with instructions on the synthesis and dosage of hundreds of psychedelics, as well as vivid trip reports by shulgin and the small group of friends on whom hed test his latest creations. Users and researchers have discovered faster and more efficient ways of delivering psychoactive drugs to the brain thus intensifying their effects and increasing their abuse liability. The dea estimates that 80 percent of us and canadian police arrested a ring of dealers who had been importing bulk mdma powder from the netherlands into canada for processing into tablets and subsequent trade across the us border. The only problem with this book is that though published in 2001, its information about mdma nuerotoxicity is also out of date as dr. Confessions of a middleaged ecstasy eater books the guardian. In the medical literature it is usually maintained that mdma was. However, safrole is now rather hard to get hold of, precisely because it is so easy to synth mdma from it.
It produces feelings of increased energy, euphoria, emotional. Using prior knowledge, making connections, questioning, visualizing, inferring, summarizing, evaluating and synthesizing. A complete mdma synthesis for the first time chemist kindle edition by dean stone author see all 2 formats and editions hide other formats and editions. The mixture is heated with a boiling water bath for 6 hours. An optimal dose for experiencing the typical range of psychedelic experiences is usually. Although first patented by merck in 1912 as a precursor to a new pharmaceutical, the pharmacological effects were not studied until fifteen years later whilst the recreational use of mdma remained relatively unknown until. This is not the best synthesis in terms of conditions, or yield, but its by far the simplest. The desired effects include altered sensations, increased energy, empathy, as well as pleasure. Pour it into the flask that contains the mdma oil, and drop the stirbar in too. Structural biochemistrymdma wikibooks, open books for an.
The synthesis of mdp2p from betanitroisosafrole might be useful, but most often betanitroisosafrole is used to produce mda directly. If you do not have exceptional chemistry experience and lack an appropriate approval from the respective drug enforcement agency in your country, do not follow and apply the methods as outlined here. Synthesis instructions exist which can be followed by an amateur with very little knowledge of chemistry. Mdma has remained a schedule i substance since then, with the exception of a brief period of time between 1987 and 1988. When her financial aid is cut, she uses her book and street smarts, along with the schools resources to synthesize the growing popular drug, ecstasy. This genius chemist spent 50 years creating psychedelic. However, people with less than 2 years of college chemistry experience would probably not be capable of sucessfully synthesizing. Adam administration alcohol alexander shulgin amphetamine aphrodisiac began behavioral body brain called cancer chapter chemical claudio naranjo clients clinical cocaine compounds conducted consciousness creative dosage doses of mdma drug abuse ecstasy effects of mdma emotional empathogens empathy enhance entactogen experienced explore fear.
Merck patent for synthesizing methylhydrastinine from mdma. An alternate process for the synthesis of this amide involved holding at reflux for 16 h a solution of 10 g of mda as. Originally known as methylsafrylaminc, it was intended as a parent compound to synthesize medications that control bleeding, not to control appetite as is often incorrectly cited. If you are the least unsure, do a dry run before you commit the real chemicals. From pepper to mda experiments, hive methods discourse mdma. For those interested in the techniques involved in synthesizing mdma, a good book for self learning is the following. Brain imaging shows that it affects neurons that use the chemical serotonin to. He is credited with introducing mdma ecstasy, mandy or molly to psychologists in the late 1970s for psychopharmaceutical use and for the discovery, synthesis and. In 1991 and 1997, he and his wife ann shulgin compiled the books pihkal. Lsd is highly potent, as tiny doses of 75150 micrograms. Jul, 2001 mdma 3, 4 methylenedioxymethamphetamine is a synthetic drug which has the stimulant properties of amphetamines. It is a relatively complicated goal for a newbie and a large amount of reading and understanding is required if you hope to be successful. Into the book is a reading comprehension resource for elementary students and teachers. In 1952 mdma appeared again at merck in the form of a brief note that flies exposed to the substance became unconscious, then died.
Ok i just found this file a few days ago and i wanted to post it as to let the chemists look at it and tell me what they think. Patent filed 24 december 1912 and granted 15 october 1914. Jun 03, 2014 he was nearly 70 by the time he became known as the godfather of ecstasy, a title that made it sound like he had invented mdma, which he hadnt. Synthesis of mdma mdma is a semisynthetic compound which can be made relatively easily from available precursors.
Mdma 3, 4 methylenedioxymethamphetamine is a synthetic drug which has the stimulant properties of amphetamines. Alexander shulgin and ann shulgin, published in 1991. Mdma and the effects the drug has on a person sarah cedillo tusculum college mdma methylenedioxymethamphetamine, also known as ecstasy, is a synthetic drug that has similarities to both the stimulant amphetamine and the hallucinogen mescaline baselt, 2011. Merck patent for synthesizing methylhydrastinine from. To a solution of 15 grams of piperonal in 80 ml glacial acetic acid, add 15 ml nitroethane followed by 10g of cyclohexylamine. It is also an individual journey as what sources and materials are available easily for one person, may not be available for another.
The first human tests may have occurred in 1959 or shortly thereafter. Mdma is a methamphetamine derivative and powerful cns stimulant, which is taken at dance clubs and parties under the street name of ecstasy. Adverse effects include addiction, memory problems. Demethylation vanillineugenol and methylenation piperonalsafrole a reexamination of the methylenation reaction.
However, people with less than 2 years of college chemistry experience would probably not be capable of sucessfully synthesizing mdma, and would either botch it in the best case or kill themselves in the worst case. The best way to get cocaine, if you dont have a dealer, is to talk to a hooker. Manufacturing ecstasy requires several toxic chemicals, including formaldehyde, mercury, and ammonium chloride, which is often used as a fertilizer. A must, throughout this text, pages from this book will be mentioned. It causes one to experience feelings of increased energy, euphoria, emotional warmth and. Jun 04, 2007 however, people with less than 2 years of college chemistry experience would probably not be capable of sucessfully synthesizing mdma, and would either botch it in the best case or kill themselves in the worst case. First of all i m going to tell you if you would want to make mdma you would need a.
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